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Abstract
Five major classes of non-viral gene delivery vectors are examined for their potential in precision medicine.
- Non-viral vectors may offer improved safety profiles compared to traditional viral vectors.
- Lipid Nanoparticles (LNP), polyplexes, lipoplexes, and exosomes are evaluated for their structural features and delivery mechanisms.
- Hybrid systems that combine properties from different vectors may help to address specific limitations of single-component systems.
- The review discusses therapeutic applications and translational challenges associated with these non-viral delivery platforms.
- An integrated framework is proposed to enhance the understanding of non-viral vector design for gene delivery.
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