Genetic insights into the risk of metabolic syndrome and its components on psoriasis: A bidirectional Mendelian randomization

Aug 2, 2023The Journal of dermatology

Genetic links between metabolic syndrome risk and psoriasis in both directions

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Abstract

Metabolic syndrome (MetS) is associated with a 17% increased risk of psoriasis.

Waist circumference (WC) is linked to a 65% higher risk of developing psoriasis.
Hypertension is associated with more than double the risk of psoriasis (202%).
No causal relationship was found between psoriasis and metabolic syndrome or its individual components.
Genetic evidence suggests that managing MetS and its components could help reduce psoriasis risk.

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The role of metabolic syndrome (MetS) on psoriasis has been explored only in observational studies. We conducted this bidirectional Mendelian randomization (MR) to clarify the causal relationship between MetS and its components and psoriasis. The genetic instruments of MetS and its five components (waist circumference [WC], hypertension, fasting blood glucose [FBG], triglycerides [TG], and high-density lipoprotein cholesterol [HDL-C]) were obtained from public genome-wide association studies (GWAS). Outcome datasets for psoriasis were collected from the FinnGen Biobank Analysis Consortium. The main method was inverse variance weighting, complemented by sensitivity approaches to rectify potential pleiotropy. MetS, WC, and hypertension increase the risk of psoriasis (MetS, odd ratios [OR] = 1.17, 95% confidence interval [CI] 1.08-1.27, p = 1.23e-04; WC, OR = 1.65, 95% CI 1.42-1.93, p = 1.06e-10; hypertension, OR = 2.02, 95% CI 1.33-3.07, p = 0.0009). In the reverse analysis, no causal association between psoriasis and MetS and its five components was identified. We provide novel genetic evidence that MetS, WC, and hypertension are risk factors for the development of psoriasis. Early management of MetS and its components may be an effective strategy to decrease the risk of psoriasis.

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Genetic insights into the risk of metabolic syndrome and its components on psoriasis: A bidirectional Mendelian randomization

Abstract

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