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Genetic variants in human CLOCK associate with total energy intake and cytokine sleep factors in overweight subjects (GOLDN population)
Genetic differences in the human body clock relate to total energy intake and sleep-related immune factors in overweight people
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Abstract
Four of five CLOCK gene polymorphisms were significantly associated with total energy intake in 1100 participants.
- SNP rs3749474 was linked to higher energy intake, total fat, protein, and carbohydrate consumption among minor allele carriers.
- Individuals with the minor allele were 1.33 times more likely to have high energy intake compared to non-carriers.
- All CLOCK SNPs correlated with plasma cytokine levels, especially those associated with energy intake, such as MCP1, IL-6, and adiponectin.
- Minor allele carriers with high energy intake exhibited lower cytokine values, which may relate to decreased appetite and sleep.
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