Genes that influence the body's internal clock

Nearly all organisms exhibit time-dependent behavior and physiology known as circadian rhythms.

• Circadian rhythms are influenced by a core transcription/translation feedback loop.
• Cyclic gene expression patterns regulate processes like metabolism, hormone activity, and nerve function.
• Daily inputs, such as light and food, help synchronize these cellular clocks.
• Disruption of the feedback loop may lead to various disorders and diseases.
• This has prompted increased interest in developing circadian-based therapies.

Simplified