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Synchronization of the mammalian circadian timing system: Light can control peripheral clocks independently of the SCN clock
Light can reset body clocks outside the brain's main clock to better align the body's daily rhythms with the environment
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Abstract
New experiments indicate that resetting of the circadian system may occur in a more federated and tissue-specific manner.
- Cellular circadian clocks regulate 24-hour rhythms in behavior and physiology in mammals.
- Complex environments present multiple conflicting time signals that require flexible adaptation mechanisms for endogenous rhythms.
- Traditionally, circadian entrainment has been viewed as a hierarchical process centered on a master pacemaker in the hypothalamus.
- Findings suggest that circadian timekeeping may be more resilient to disruptions and adaptable to changes in the environment.
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