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The light‐dark cycle controls peripheral rhythmicity in mice with a genetically ablated suprachiasmatic nucleus clock
The light-dark cycle controls daily rhythms in body organs of mice without the main brain clock
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Abstract
Deletion of the SCN clock in a mouse model resulted in impaired locomotor activity and arrhythmic clock gene expression.
- The SCN clock was efficiently abolished, confirming its deletion in the mouse model.
- Peripheral clocks remained rhythmic and synchronized to the light-dark cycle even without the SCN clock.
- Adaptation to a shifted light-dark cycle was faster in mice lacking the SCN clock.
- Initially, the rhythmicity of peripheral clock gene expression was dampened under constant conditions, leading to eventual desynchronization after several days.
- Findings indicate that synchronization of peripheral clocks to the light-dark cycle may occur through mechanisms independent of the SCN clock.
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