Circadian clock network desynchrony promotes weight gain and alters glucose homeostasis in mice

Mice lacking the central circadian clock develop adiposity and impaired glucose metabolism in constant darkness.

• Behavioral and tissue clock rhythms remain stable under rhythmic light but quickly deteriorate in constant darkness.
• Loss of behavioral and molecular rhythms is associated with increased body fat and reduced glucose utilization.
• Time-restricted feeding can restore peripheral clock rhythms, leading to normalization of body weight and glucose metabolism.
• An overall synchronized circadian clock network is important for maintaining metabolic balance.

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