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Nonphotic entrainment of central and peripheral circadian clocks in mice by scheduled voluntary exercise under constant darkness
Scheduled voluntary exercise resets internal body clocks in the brain and other organs of mice kept in constant darkness
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Abstract
Mice exposed to daily exercise in constant darkness showed a reorganization of their internal circadian rhythms.
- Scheduled exercise under constant darkness is associated with a steady-state entrainment of behavioral circadian rhythms.
- Mice in a new cage with a running wheel demonstrated altered internal temporal order of clock gene expression compared to those under constant darkness.
- The temporal order of circadian rhythms was maintained in the suprachiasmatic nucleus and peripheral tissues but not in the arcuate nucleus.
- Free-running mice exhibited a shortening of the behavioral rhythm compared to those exposed to a light-dark cycle.
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