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Scheduled exposures to a novel environment with a running‐wheel differentially accelerate re‐entrainment of mice peripheral clocks to new light–dark cycles
Using a running wheel in a new environment speeds up how mice's body clocks adjust to changed light-dark schedules in different ways
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Abstract
Scheduled exposures to a novel environment with a running-wheel may accelerate re-entrainment of mouse peripheral clocks to 8-hour shifted light-dark cycles.
- In a phase-advance shift, the circadian rhythm in locomotor activity fully re-entrained in the exposed group, while it was only transient in the control group.
- Per1 expression in the suprachiasmatic nucleus (SCN) re-entrained almost completely in both the control and exposed groups during the phase-advance shift.
- The circadian rhythm of Per1 expression in skeletal muscle and lung fully re-entrained in the exposed group, but not in the control group.
- In a phase-delay shift, both groups showed nearly complete re-entrainment of circadian rhythms in locomotor activity and Per1 expression.
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