Mistimed wheel running interferes with re‐entrainment of circadian Per1 rhythms in the mouse skeletal muscle and lung

Jan 29, 2016Genes to cells : devoted to molecular & cellular mechanisms

Running at the wrong time disrupts daily Per1 gene rhythms in mouse muscle and lung

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Abstract

Re-entrainment of circadian Per1 rhythm in skeletal muscle and lung was significantly decelerated by wheel running at the end of the shifted dark phase.

Wheel running did not influence re-entrainment of circadian rhythms during the phase-advance protocol.
In the phase-delay protocol, wheel running did not affect the re-entrainment of the circadian locomotor rhythm.
Re-entrainment of circadian Per1 rhythm was significantly slowed in both skeletal muscle and lung tissues.
The effects of wheel running on re-entrainment vary depending on the time of day and the specific peripheral tissues involved.
Mistimed wheel running may disrupt the re-entrainment of circadian rhythms.

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Previously, we showed the acceleration of re-entrainment to 8-h phase-advanced light/dark cycles (LD) in the circadian Per1 expression rhythms of the mouse lung and skeletal muscle by 3-h wheel running (WR) at the beginning of shifted dark phase. In the present study, the effects of WR at the end of shifted dark phase were examined on the re-entrainment in mice. LD was advanced by shortening and was delayed by lengthening the first light period in the phase-advance and phase-delay protocol, respectively. Shifted LD was continued for 4 days, which was followed by constant darkness (DD). Per1 expression was measured in the cultured tissues obtained on the first day of DD from mice carrying a bioluminescence reporter of Per1 expression. In the phase-advance protocol, re-entrainment was not influenced by WR in any circadian rhythm examined. In the phase-delay protocol, re-entrainment of the circadian locomotor rhythm was not affected by WR. However, re-entrainment of circadian Per1 rhythm was significantly decelerated in the skeletal muscle and lung. These findings indicate that the effects of WR on re-entrainment depend on the time of day and the peripheral tissues. Mistimed WR interferes with re-entrainment of circadian rhythms in the lung and skeletal muscle.

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Mistimed wheel running interferes with re‐entrainment of circadian Per1 rhythms in the mouse skeletal muscle and lung

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