Running at the wrong time disrupts daily Per1 gene rhythms in mouse muscle and lung

Re-entrainment of circadian Per1 rhythm in skeletal muscle and lung was significantly decelerated by wheel running at the end of the shifted dark phase.

• Wheel running did not influence re-entrainment of circadian rhythms during the phase-advance protocol.
• In the phase-delay protocol, wheel running did not affect the re-entrainment of the circadian locomotor rhythm.
• Re-entrainment of circadian Per1 rhythm was significantly slowed in both skeletal muscle and lung tissues.
• The effects of wheel running on re-entrainment vary depending on the time of day and the specific peripheral tissues involved.
• Mistimed wheel running may disrupt the re-entrainment of circadian rhythms.

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