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Genetics of circadian rhythms and mood spectrum disorders
Genetic links between body clock patterns and mood disorders
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Abstract
Altered circadian rhythms may be biological markers of mood spectrum disorders.
- Circadian deregulations occur during acute mood episodes and euthymic periods, particularly in bipolar patients in remission.
- Rhythm dysfunctions in mood disorder patients have been observed using actigraphic measures and assessments of social rhythms, diurnal preferences, and melatonin secretion.
- Certain circadian gene variants may be associated with susceptibility to mood spectrum disorders.
- Connections to circadian genes such as CLOCK, ARNTL1, NPAS2, PER3, and NR1D1 have been frequently noted in bipolar disorders.
- The exploration of circadian phenotypes and genes in mood spectrum disorders could help identify their pathophysiological determinants.
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