Circadian genes, rhythms and the biology of mood disorders

Mar 31, 2007Pharmacology & therapeutics

Body Clock Genes, Daily Rhythms, and Mood Disorders

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Abstract

Abnormalities in circadian rhythms may be linked to the development of mood disorders such as bipolar disorder and major depression.

  • Circadian rhythms are thought to influence mood regulation and could play a role in mood disorders.
  • Certain treatments for mood disorders, like total sleep deprivation and bright light therapy, may work by resetting the circadian clock.
  • Mood stabilizers and antidepressants might achieve some of their effects by impacting the circadian clock.
  • Recent studies have identified specific genes involved in circadian rhythms that are associated with mood regulation.
  • The roles of these genes in brain areas and neurotransmitter systems related to mood are increasingly recognized.

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