Lack of GHSR gene and LEAP2 treatment increase liraglutide’s blood sugar lowering effects in male mice depending on their metabolic state

GHSR inhibition may enhance the glucose-lowering effects of liraglutide.

• Liraglutide is effective in lowering blood sugar levels in individuals with type 2 diabetes and obesity.
• Activation of the growth hormone secretagogue receptor is associated with increased blood sugar levels.
• Inhibiting GHSR may improve the effectiveness of liraglutide in reducing blood sugar.

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