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Ginsenoside Rb3 modulates gut microbiota to alleviate cerebral inflammation and ferroptosis via the NLRP3/NF-κB/GPX4 pathway in rats with cerebral ischemia/reperfusion injury
Ginsenoside Rb3 changes gut bacteria to reduce brain inflammation and cell death in rats after stroke injury
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Abstract
Rb3 reduced cerebral infarct volume and improved neurological deficits in CIRI rats.
- Rb3 decreased blood-brain barrier permeability in cerebral ischemia/reperfusion injury.
- The treatment mitigated cerebral ferroptosis and neuroinflammation, indicated by lower iron levels and reduced inflammatory markers.
- Rb3 improved the GSH/GSSG ratio and lowered levels of TNF-α, IL-1β, and IL-6.
- Intestinal inflammation was alleviated, and gut microbiota dysbiosis was corrected with Rb3 treatment.
- Fecal microbiota transplants from Rb3-treated rats conferred similar protective effects in pseudo germ-free rats.
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