International journal of medical sciences

Ginsenoside Rg1 improves memory problems in aging mice by restoring brain growth and survival signals to prevent cell death

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

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Abstract

Rg1 significantly improved spatial learning and memory in aging mice.

  • Chemically induced aging in mice was achieved through D-galactose and AlCl administration.
  • Performance improvements were observed in step down avoidance tests and Morris water maze experiments.
  • Rg1 restored the decline of FGF2 and BDNF levels associated with aging.
  • Reactivation of the TrkB/Akt signaling pathways in the hippocampus and prefrontal cortex was noted.
  • Rg1 antagonistically restored the expression of the anti-apoptotic protein Bcl-2 and the apoptosis-promoting enzyme cleaved-Caspase3.

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Funding

Competing interests

Competing Interests: The authors have declared that no competing interest exists.
PubMed

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