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The clinicopathological significance and relationship of Gli1, MDM2 and p53 expression in resectable pancreatic cancer
The importance and link between Gli1, MDM2, and p53 levels in removable pancreatic cancer
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Abstract
In 57 cases of pancreatic cancer, expression levels of Gli1, MDM2, and p53 were significantly higher than in normal pancreatic tissues.
- Higher expression of Gli1, MDM2, and p53 is positively associated with tumor UICC stage and T stage.
- Patients with Gli1 expression alone or coexpression of Gli1 and MDM2 exhibited significantly worse overall survival compared to those with negative expression.
- Knockdown of p53 increased Gli1 levels while decreasing MDM2 levels, enhancing cell invasion and migration in cells with wild-type p53.
- Knockdown of Gli1 or MDM2 did not affect p53 expression but reduced the levels of MDM2 or Gli1, respectively, and inhibited cell invasion and migration in mutant p53 cells.
- Overexpression of Gli1, MDM2, and mutant p53 may contribute to the progression of pancreatic cancer and is associated with patient prognosis.
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