How support cells and the brain’s protective barrier interact in Alzheimer's disease

Dysfunction of the blood-brain barrier (BBB) may play a significant role in the onset and progression of Alzheimer’s disease (AD).

• Alzheimer's disease is characterized by irreversible neurodegeneration, with senile plaques and neurofibrillary tangles being common features.
• Currently, no effective curative therapies exist for Alzheimer's disease.
• The blood-brain barrier serves as a selective barrier that helps maintain brain homeostasis.
• Injury to the blood-brain barrier could contribute to Alzheimer’s disease pathogenesis, though the exact mechanisms remain unclear.
• Glial cells are suggested to play a crucial role in maintaining the integrity of the blood-brain barrier and supporting neuronal function.

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