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Microglia-Mediated Neurovascular Unit Dysfunction in Alzheimer’s Disease
Microglia-related problems in the brain's blood flow system in Alzheimer's disease
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Abstract
Microglia are associated with multiple mechanisms of dysfunction in Alzheimer's disease.
- Microglia contribute to breakdown through neuroinflammation and oxidative stress.
- They induce mitochondrial dysfunction in neurons, affecting energy balance and cellular health.
- Microglia can promote abnormal contraction of cerebral vessels and loss of pericytes in Alzheimer's disease.
- Dysfunction in astrocytes and pericytes, mediated by microglia, may compromise the integrity of the neurovascular unit.
- Therapeutic advancements are being explored to restore microglial and neurovascular unit functions in Alzheimer's disease.
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