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Abstract
Glial-conditional Aqp4 knockout mice showed a 31% reduction in brain water uptake after systemic hypoosmotic stress.
- Astroglial AQP4 is essential for regulating water exchange at the blood-brain interface.
- Conditional knockout of the Aqp4 gene eliminated AQP4 in the brain without affecting endothelial pools.
- Immunofluorescence and quantitative analysis confirmed the absence of AQP4 signals in capillary endothelia.
- Deletion of astroglial AQP4 delayed postnatal resorption of brain water.
- The findings indicate that the blood-brain barrier may be more complex than previously understood.
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