Current psychiatry reports

Brain effects and possible mental health impacts of GLP-1 and combined GIP/GLP-1 receptor drugs based on systematic evaluation

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Abstract

The review assesses evidence linking GLP-1 and GIP/GLP-1 receptor agonists with neuropsychiatric outcomes.

  • Evidence was evaluated using the Bradford Hill criteria for assessing causality.
  • Linkages between GLP-1 exposure and various neuropsychiatric outcomes were examined.
  • Potential neuropsychiatric effects associated with GIP/GLP-1 receptor agonists were also considered.
  • Findings may suggest important implications for understanding the impact of these treatments on mental health.

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