BMJ open diabetes research & care

Treatment with GLP-1 and combined GIP/GLP-1 medications in MODY: a case series

Updated

Abstract

GLP-1 receptor agonists reduced HbA1c by 1.3% in patients with HNF1A and HNF4A types of maturity-onset diabetes of the young (MODY).

  • In patients with HNF1A-MODY and HNF4A-MODY, GLP-1 receptor agonists also decreased body mass index (BMI) by 2.90 kg/m and reduced sulfonylurea dose by 66.6%.
  • Dual GIP/GLP-1 receptor agonist treatment resulted in a non-statistically significant HbA1c decrease of 1.8% and a significant BMI reduction of 8.73 kg/m.
  • All patients receiving dual GIP/GLP-1 receptor agonists who were on sulfonylurea discontinued its use, with one patient also stopping insulin.
  • For ABCC8-MODY and HNF1B-MODY patients, GLP-1 receptor agonists lowered HbA1c by 1.2% and 1.8%, and BMI by 1.1 kg/m and 1.2 kg/m, respectively.
  • Patients with ABCC8-MODY and HNF1B-MODY no longer required sulfonylurea and insulin treatments, respectively.

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Funding

Competing interests

Competing interests: DTB, MFdF, EAO and BEG receive grant support from the Caswell Diabetes Institute and from the National Institutes of Health (grant U54DK118612-04). EAO and MFdF are funded by the National Institutes of Health (grant R01DK125513). Duality of Interest. DTB is a research investigator for Fractyl Health Laboratories, Sanofi, the Type 1 Diabetes Exchange (T1DX-QI), and Rhythm Pharmaceuticals. MFdF is an advisory board member for PTC Pharmaceuticals and was a scientific presenter in a symposium funded by Amryt Pharmaceuticals. EAO has received grant support from Aegerion Pharmaceuticals (manufacturer of metreleptin), Akcea Therapeutics, Ionis Pharmaceuticals, Gemphire Therapeutics, Novo Nordisk, Rhythm Pharmaceuticals, Fractyl Health Laboratories and GI Dynamics. EAO has served as an advisor and/or a consultant to Aegerion Pharmaceuticals, Akcea Therapeutics, Ionis Pharmaceuticals, and Regeneron. EAO has royalty rights from the use of metreleptin in lipodystrophy. WHH is on data safety and monitoring boards for Merck Sharp & Dohme and Rivus Pharmaceuticals. No other potential conflicts of interest relevant to this article were reported.
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