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GLP ‐1 Receptor Agonists Versus Bariatric Surgery: Effects of Weight Loss and BMI on Subsequent General Surgical Procedures
Weight Loss and BMI Effects on Later Surgeries: Comparing GLP-1 Medicines and Weight-Loss Surgery
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Abstract
A total of 9,470 individuals underwent general surgery procedures, with metabolic bariatric surgery () leading to a mean reduction of -9.89 compared to glucagon-like peptide-1 receptor agonists ().
- Patients receiving MBS had a higher initial BMI, with 60.8% having a BMI of 40 or greater compared to 24.5% of those receiving GLP-1RA.
- Higher BMI at the time of surgery is associated with increased postoperative complications and longer hospital stays.
- MBS is linked to lower odds of complications compared to GLP-1RA.
- The findings suggest that preoperative weight loss interventions may improve surgical outcomes for patients with obesity and type 2 diabetes mellitus.
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Key numbers
-9.89
Mean Reduction
Difference in reduction between and treatments.
1.01
Complication Odds Ratio
Odds ratio for complications per 1 unit increase in at surgery.
0.87
Lower Complication Odds with
Odds ratio for complications in patients with prior compared to .