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Alternative dosing regimens of GLP ‐1 receptor agonists may reduce costs and maintain weight loss efficacy
Different dosing schedules of GLP-1 drugs may lower costs while keeping weight loss effective
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Abstract
Switching from one dose per week to one dose every 2 weeks maintains roughly 75% of weight loss.
- Reducing the frequency of doses does not significantly impact weight loss efficacy.
- Increasing the dose size while decreasing frequency may maintain nearly 100% of weight loss.
- Offering a biweekly dosing regimen allows for treating twice as many obese adults without increasing costs.
- This approach could lead to greater reductions in national obesity and mortality rates compared to traditional weekly dosing.
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Key numbers
75%
Weight Loss Retention with
Weight loss retention when switching from to
50%
Cost Reduction with Increased Dose Size
Cost reduction when switching from 1.7 mg to 2.4 mg
1.0 × 10 5
Lives Saved with
Estimated lives saved annually with for 50% of obese US adults