Journal of neurology

Nerve problems in type 2 diabetes linked to GLP-1 receptor drugs compared to DPP-4 inhibitor drugs

Updated

Abstract

Diabetic peripheral neuropathy is a debilitating complication of type 2 diabetes mellitus (T2DM).

  • Diabetic peripheral neuropathy is linked to serious outcomes, including foot ulcers and amputations.
  • The use of glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in T2DM treatment raises questions about their effects on neuropathy-related complications.
  • Comparative effects of these therapies on lower-extremity complications associated with neuropathy are not well understood.

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