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Short- and long-acting GLP-1 receptor agonists decrease female sexual behaviors in experienced rodents
Short- and long-lasting GLP-1 hormone treatments reduce sexual behavior in female rodents with prior experience
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Abstract
GLP-1 receptor agonists reduced sexual behaviors in female rats and mice, suggesting species-dependent effects.
- Short-acting GLP-1 receptor agonist exendin-4 decreased various sexual behaviors in female rats.
- Long-acting agonists liraglutide and dulaglutide reduced interaction time with male mice, which may relate to lower mounting and intromission durations.
- Increased noradrenaline levels in the nucleus tractus solitarii and altered levels of glutamate, glutamine, and taurine in the lateral septum could be involved in these behavioral changes.
- Dulaglutide decreased social novelty in the three-chamber test, a behavior linked to motivation.
- Long-acting GLP-1 receptor agonists were associated with increased sociability and longer time spent seeking a novel object.
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