The combination of a glucagon-like peptide-1 and amylin receptor agonists reduces alcohol consumption in both male and female rats

A reduction in alcohol intake was observed when salmon calcitonin was added to ongoing dulaglutide treatment in both male and female rats.

• Combining salmon calcitonin and dulaglutide initially decreased alcohol intake in rats of both sexes.
• Tolerance to the treatment was noted when salmon calcitonin and dulaglutide were administered simultaneously.
• The combination of these treatments consistently reduced food consumption and body weight in both male and female rats.
• No changes were observed in inflammatory mediators or the gene expression of amylin or GLP-1 receptors.
• Alterations in fat tissue morphology were noted due to the treatment combination.

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