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Distinct Neural Sites of GLP-1R Expression Mediate Physiological versus Pharmacological Control of Incretin Action
Different Brain Areas with GLP-1 Receptors Control Natural versus Drug-Induced Incretin Effects
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Abstract
Widespread loss of neural GLP-1 receptors in mice had no effect on basal food intake or glucose homeostasis.
- The glucoregulatory effects of GLP-1 receptor agonists were maintained despite the loss of neural GLP-1 receptors.
- Selective reduction of GLP-1 receptor expression in specific neurons led to impaired glucose homeostasis and slower gastric emptying.
- This impairment also reduced the weight loss typically achieved through sustained GLP-1 receptor activation.
- Discreet neural domains of GLP-1 receptor expression play a significant role in regulating metabolism and the gut-brain communication.
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