How diabetes-related hormones may support brain cell growth and flexibility to help treat and prevent mental disorders

GLP-1 and GIP receptor agonists are associated with reduced cardiovascular mortality and stroke risk.

• These agents mimic natural hormones GLP-1 and GIP, showing effectiveness in treating diabetes and obesity.
• They have robust acute and long-term effects on weight, metabolism, and blood pressure.
• Preclinical evidence suggests they activate pathways important for brain health, including neuroplasticity and protection against cell death.
• Potential therapeutic applications include treatment for major neurocognitive disorders and substance use disorders.
• GLP-1 and GIP receptor agonists may help manage comorbid conditions that affect individuals with mental disorders.

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