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Abstract
Hemophilic arthropathy (HA) is a progressive joint disease that occurs despite effective bleeding control in hemophilia.
- HA may be initiated and maintained by a cycle involving synovial macrophage activation, blood vessel formation, and cartilage breakdown.
- These pathways are shared with conditions like osteoarthritis and inflammatory arthritis.
- Glucagon-like peptide-1 receptor agonists (GLP-1RAs) could serve as immunometabolic modulators with potential anti-inflammatory and cartilage-protecting effects.
- GLP-1RAs are being explored for their analgesic properties in the context of HA.
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