Nature cancer

Glucagon-like peptide-1 medicines and their links to cancer

Updated

Abstract

GLP-1 medicines may reduce cancer incidence among individuals with type 2 diabetes and obesity.

  • GLP-1 medicines are associated with reduced food intake, body weight, and insulin resistance.
  • These medicines may improve inflammation levels, contributing to better health outcomes.
  • Evidence suggests that GLP-1 medicines could suppress tumor development through both weight loss-dependent and weight loss-independent mechanisms.
  • Data from trials and registries indicate a potential link between GLP-1 medicines and lower rates of obesity-related cancer.

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Full Text

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Funding

Competing interests

Competing interests: J.M.Y. has no competing interests or conflict of interest. D.J.D. has served as a consultant or speaker within the past 12 months to Alnylam, Amgen, AstraZeneca, Crinetics, Eli Lilly, General Medicines Inc., Kallyope, Metsera, Novo Nordisk, Pfizer Protagonist Therapeutivs Inc and Sanofi. Neither D.J.D. nor his family members hold issued stock directly or indirectly in any of these companies. D.J.D. holds nonexercised options in Kallyope. Mt. Sinai Hospital receives grant support from Amgen, Eli Lilly and Zealand Pharma for preclinical studies in the laboratory of D.J.D.
PubMed

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