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Association between glucagon‐like peptide‐1 receptor agonist use and peri‐operative pulmonary aspiration: a systematic review and meta‐analysis
Link between using glucagon-like peptide-1 receptor drugs and lung aspiration during surgery: a systematic review and analysis
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Abstract
In a meta-analysis of 28 observational studies involving 185,414 patients, glucagon-like peptide-1 receptor agonist exposure was not associated with .
- Glucagon-like peptide-1 receptor agonist exposure is associated with an increased risk of in fasted patients undergoing procedures requiring anaesthesia.
- The odds ratio for residual gastric contents among patients using glucagon-like peptide-1 receptor agonists was 5.96 (95% CI 3.96-8.98), indicating a significant association.
- Withholding at least one dose of glucagon-like peptide-1 receptor agonist before a procedure was associated with lower odds of residual gastric contents, with an odds ratio of 0.51 (95% CI 0.33-0.81).
- Despite the increased risk of residual gastric contents, there was no evidence indicating an increased risk of pulmonary aspiration for patients using glucagon-like peptide-1 receptor agonists.
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Key numbers
5.96
Increased Odds of
comparing exposure to control group.
0.51
Lower Odds with Dose Withholding
for withholding at least one dose of .
1.04
No Increased Aspiration Risk
for exposure related to .