Glucagon-like peptide-1 receptor agonists and their impact on bone metabolism: A review and analysis of controlled trials with mainly first-generation drugs

This systematic review and meta-analysis quantified the effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on bone metabolism markers in randomized controlled trials.

• GLP-1RAs may influence bone remodeling, though prior research has shown mixed results.
• The review focuses on densitometric, biochemical, and inflammatory markers related to bone metabolism.
• Previous studies included in the analysis used varying designs and active comparators, complicating interpretations.
• This analysis aims to clarify the specific effects of GLP-1RAs compared to placebo.

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