JAMA psychiatry

Effects of Glucagon-Like Peptide 1 Receptor Agonists on Mental Health: A Review and Combined Analysis

Updated

Abstract

Eighty randomized clinical trials involving 107,860 patients were included in the meta-analysis.

  • GLP1-RA treatment is not associated with a significant difference in the risk of serious psychiatric adverse events compared to placebo.
  • There is no significant difference in nonserious psychiatric adverse events with GLP1-RA treatment versus placebo.
  • No change in depressive symptom severity was observed with GLP1-RA treatment compared to placebo.
  • GLP1-RA treatment is associated with improvements in restrained eating and emotional eating behavior.
  • Improvements in quality of life related to mental health, physical health, diabetes, and weight were noted with GLP1-RA treatment.

Simplified

Full Text

Full text is available at the source.

Funding

Competing interests

Conflict of Interest Disclosures: Dr Mizuno reported fellowship grants from Canon Foundation in Europe, consultant fees from WCG Clinical and Signant Health, and manuscript fees from Sumitomo Dainippon Pharma outside the submitted work. Dr Howes reported investigator-initiated research funding from and/or participated in advisory or speaker meetings organized by AbbVie, Alkermes, Angelini, Autifony, Biogen, Boehringer Ingelheim, Delix, Eli Lilly, Elysium, Heptares, Global Medical Education, Invicro, Janssen, Karuna, Lundbeck (where he was previously a part-time employee), Merck, Neumora, Neurocrine, Ontrack/Pangea, Otsuka, Sunovion, Teva, Recordati, Roche, ROVI Biotech, Viatris, and Mylan. Dr McCutcheon reported speaker/consultancy fees from Boehringer Ingelheim, Janssen, Karuna, Lundbeck, Newron, Otsuka, and Viatris and co-directing a company that designs digital resources to support treatment of mental ill health. Dr McGowan reported being a shareholder of Reset Health, receiving research grants from Novo Nordisk, and having received consultant fees for educational/advisory meetings from Novo Nordisk, Lilly, AstraZeneca, Janssen outside the submitted work. Dr Sen Gupta reported speaker fees/educational meeting support from Novo Nordisk outside the submitted work. Dr Ismail reported book royalties from Oxford University Press and her salary being funded in part by the National Institute for Health and Care Research (NIHR) Maudsley Biomedical Research Centre (BRC). Dr Pillinger reported receiving speaker/consultancy fees from Boehringer Ingelheim, Recordati, Lundbeck, Otsuka, Janssen, CNX Therapeutics, Sunovion, ROVI Biotech, Schwabe Pharma, and Lecturing Minds Stockholm AB; receiving book royalties from Wiley Blackwell; and co-directing a company that designs digital resources to support treatment of mental illness outside the submitted work. No other disclosures were reported.
PubMed

What Lands in Your Inbox Each Week:

  • 📚7 fresh studies
  • 📝plain-language summaries
  • direct links to original studies
  • 🏅top journal indicators
  • 📅weekly delivery
  • 🧘‍♂️always free