Glucagon like peptide-1 receptor agonists as a promising therapeutic option of metabolic dysfunction associated steatotic liver disease and obesity: hitting two targets with one shot

Feb 25, 2025Current opinion in gastroenterology

Glucagon-like peptide-1 receptor agonists as a promising treatment for fatty liver disease and obesity

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Abstract

GLP-1 receptor agonists have shown potential benefits for liver function in patients with metabolic dysfunction-associated steatotic liver disease (MASLD).

  • GLP-1 receptor agonists are effective in controlling blood sugar levels and promoting weight loss.
  • They may improve cardiovascular and kidney function in addition to their metabolic benefits.
  • GLP-1 influences glucose metabolism, appetite, and insulin sensitivity, which could affect liver fat deposition.
  • Recent advancements include new formulations and dosing options for GLP-1 receptor agonists, expanding their use.
  • Emerging dual and triple hormonal agonists may offer future therapeutic strategies for managing MASLD.

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