Acta neuropsychiatrica

Link between glucagon-like peptide-1 receptor agonists and brain cell growth: a systematic review

Updated

Abstract

GLP-1 and GLP-1 receptor agonists may increase neurogenesis in several brain regions.

  • GLP-1 and GLP-1 receptor agonists have been observed to increase neurogenesis in the dentate gyrus, hippocampus, olfactory bulb, and medial striatum in animal models.
  • Modulatory effects were noted in multiple apoptotic pathways related to neurogenesis.
  • GLP-1 and GLP-1 receptor agonists are associated with the upregulation of survival pathways in neuronal systems.
  • These findings suggest potential benefits for mental disorders characterized by neurogenesis defects.

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Full Text

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Funding

Competing interests

Dr Roger S. McIntyre has received research grant support from CIHR/GACD/National Natural Science Foundation of China (NSFC) and the Milken Institute; speaker/consultation fees from Lundbeck, Janssen, Alkermes, Neumora Therapeutics, Boehringer Ingelheim, Sage, Biogen, Mitsubishi Tanabe, Purdue, Pfizer, Otsuka, Takeda, Neurocrine, Sunovion, Bausch Health, Axsome, Novo Nordisk, Kris, Sanofi, Eisai, Intra-Cellular, NewBridge Pharmaceuticals, Viatris, Abbvie, Atai Life Sciences. Dr Roger McIntyre is a CEO of Braxia Scientific Corp. Kayla M. Teopiz has received fees from Braxia Scientific Corp. Dr Joshua D Rosenblat has received research grant support from the Canadian Institute of Health Research (CIHR), Physician Services Inc. (PSI) Foundation, Labatt Brain Health Network, Brain and Cognition Discovery Foundation (BCDF), Canadian Cancer Society, Canadian Psychiatric Association, Academic Scholars Award, American Psychiatric Association, American Society of Psychopharmacology, University of Toronto, University Health Network Centre for Mental Health, Joseph M. West Family Memorial Fund and Timeposters Fellowship and industry funding for speaker/consultation/research fees from iGan, Boehringer Ingelheim, Janssen, Allergan, Lundbeck, Sunovion, and COMPASS. He is the Chief Medical and Scientific Officer of Braxia Scientific and the medical director of the Canadian Rapid Treatment Centre of Excellence (Braxia Health). Dr Rodrigo B. Mansur has received research grant support from the Canadian Institute of Health Research; Physicians’ Services Incorporated Foundation; the Baszucki Brain Research Fund; and the Academic Scholar Awards, Department of Psychiatry, University of Toronto. Hezekiah C.T. Au, Yang Jing Zheng, Gia Han Le, Sabrina Wong, Hartej Gill, Sebastian Badulescu, and Kyle Valentino have no conflicts to declare.
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