Effects of Glucagon-Like Peptide-1 Receptor Drugs During Early Pregnancy on Birth Outcomes

An increasing number of women of childbearing age are using glucagon-like peptide-1 receptor agonists (GLP-1 RAs).

• Effective contraception is recommended for women using GLP-1 RAs.
• Maternity services are seeing more cases of women exposed to GLP-1 RAs around conception or during pregnancy.
• The actual prevalence of GLP-1 RA exposure in pregnancy may be underestimated due to inconsistent routine inquiries.
• The impact of GLP-1 RA exposure on pregnancy outcomes is not well understood.
• Limited guidance exists for counseling women who have unintentionally been exposed to GLP-1 RAs during conception.

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