Heart benefits of two diabetes drug types: GLP-1 receptor activators versus SGLT2 inhibitors

Funding Support and Author Disclosures This study was partially funded through the National Institutes of Health grants K23 HL153775, R01 LM006910, R01 HG006139, R01HL69954, R01HL169171, R35GM160458, and T15LM00707934 and an Intergovernmental Personnel Act agreement with the U.S. Department of Veterans Affairs. The funders had no role in the design and conduct of the protocol; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. Dr Bu has received support from the U.S. Food and Drug Administration, Gates Foundation, and Patient-Centered Outcomes Research Institute outside of the scope of this work. Dr Ostropolets is an employee of Janssen Research and Development. Dr Lau received research funding from Diabetes UK outside the scope of this work. Dr Man has received support from the C.W. Maplethorpe Fellowship, the National Institute of Health Research, European Commission Framework Horizon 2020, the Hong Kong Research Grant Council, and the Innovation and Technology Commission of the Hong Kong Special Administration Region Government outside the scope of this work. Dr Morales is supported by a Wellcome Trust Clinical Research Fellowship. Ms Van Zandt is an employee and shareholder of IQVIA. Ms Yin is employee of IQVIA. Dr Khera is an associate editor at JAMA; has received support from the Doris Duke Charitable Foundation, Bristol Myers Squibb, Novo Nordisk, and BridgeBio outside the scope of this work; and is a cofounder of Evidence2Health and Ensight-AI. Dr Hripcsak have received contracts and grants from the U.S. Food and Drug Administration, the U.S. National Institutes of Health, and Janssen Research & Development outside the scope of this work. Dr Suchard have received contracts and grants from the U.S. Food and Drug Administration, the U.S. National Institutes of Health, and Janssen Research & Development outside the scope of this work; and receives contracts from Gilead Sciences outside the scope of this work. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.