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Variability in and predictors of glycaemic responses after 24 weeks of treatment with exenatide twice daily and exenatide once weekly
Differences and factors influencing blood sugar responses after 24 weeks of twice-daily versus once-weekly exenatide treatment
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Abstract
Among 2355 participants, the change in glycated haemoglobin () after 24 weeks ranged from -0.3% to -3.6% depending on the regimen.
- Baseline HbA1c levels correlated with changes in HbA1c (P < .0001).
- twice daily showed a change in HbA1c from -0.3% to -3.2%, while exenatide once weekly ranged from -0.5% to -3.6%.
- Older age and Asian ethnicity were associated with higher responses to exenatide twice daily.
- No specific factors were significantly linked to response for exenatide once weekly.
- These findings may help estimate the likelihood of achieving HbA1c goals based on individual baseline levels.
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Key numbers
-0.3% to -3.2%
Change Range ( Twice Daily)
25th to 75th percentile of change after 24 weeks
2.1×
Increased Odds for Asian Participants
Odds of being in the high-responder tertile compared to non-Asian participants