Investigative ophthalmology & visual scienceOct 3, 2001

Changes in mucus-producing eye cells and mucus gene activity in a mouse allergy model

Circadian Biology Weekly Brief ↗PubMed ↗

Updated Apr 1, 2026

Abstract

The number of filled goblet cells significantly decreased after allergen challenge, with a P value of < 0.001.

Both cat dander and the peptide P3-1 resulted in a significant reduction in filled goblet cells at 6 hours after challenge.
The number of filled goblet cells began to recover toward naïve levels by 24 hours and returned to naïve levels by 48 hours.
Muc5AC and Muc4 mRNA levels were decreased during allergen challenge, with Muc5AC showing a rebound increase at 24 hours post-challenge.
By 48 hours, Muc5AC mRNA levels returned to the range seen in naïve controls, while Muc4 mRNA levels remained significantly reduced at most time points.

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