Full text is available at the source.
The Gut–Brain Axis in Autism: Inflammatory Mechanisms, Molecular Insights, and Emerging Microbiome-Based Therapies
The Gut-Brain Connection in Autism: Inflammation, Molecular Details, and New Microbiome Treatments
AI simplified
Abstract
Individuals with autism spectrum disorder (ASD) frequently exhibit dysbiosis, characterized by an imbalance in gut microbial composition.
- Gut dysbiosis in ASD is associated with reduced microbial diversity and increased intestinal permeability.
- These microbial changes contribute to systemic inflammation, which may affect brain function.
- Alterations in gut microbiota could influence neurotransmitter synthesis and metabolic functions.
- Therapeutic approaches targeting the gut microbiome, such as probiotics and dietary modifications, have shown potential in alleviating gastrointestinal and ASD-related symptoms.
- Emerging evidence suggests that the gut-brain axis plays a crucial role in the pathophysiology of ASD.
AI simplified