Gut-brain axis through the lens of gut microbiota and their relationships with Alzheimer's disease pathology: Review and recommendations

Feb 3, 2023Mechanisms of ageing and development

Gut bacteria and their links to Alzheimer's disease through the gut-brain connection: Review and suggestions

AI simplified

Gut-Brain Axis on OpenScience ↗PubMed ↗DOI ↗

Abstract

Alterations in gut microbiome composition and diversity are observed in both animal models and human patients with Alzheimer's disease.

Gut microbiome dysbiosis is associated with increased intestinal permeability and impairment of the blood-brain barrier.
Neuroinflammation linked to gut microbiome changes may contribute to the development of Alzheimer's disease hallmarks.
Modulation of the gut microbiome could potentially alleviate symptoms of Alzheimer's disease or serve as a preventive measure.
Type 2 Diabetes Mellitus frequently coexists with Alzheimer's disease, sharing common gut microbiome alterations and inflammatory responses.
Exploration of therapies such as fecal microbiota transplantation and precision medicine may benefit Alzheimer's disease management.

AI simplified

Alzheimer's disease (AD) is a neurodegenerative disorder that affects millions of people worldwide. Growing evidence suggests that the gut microbiome (GM) plays a pivotal role in the pathogenesis of AD through the microbiota-gut-brain axis (MGB). Alterations in GM composition and diversity have been observed in both animal models and in human patients with AD. GM dysbiosis has been implicated in increased intestinal permeability, blood-brain barrier (BBB) impairment, neuroinflammation and the development of hallmarks of AD. Further elucidation of the role of GM in AD could pave way for the development of holistic predictive methods for determining AD risk and progression of disease. Furthermore, accumulating evidence suggests that GM modulation could alleviate adverse symptoms of AD or serve as a preventive measure. In addition, increasing evidence shows that Type 2 Diabetes Mellitus (T2DM) is often comorbid with AD, with common GM alterations and inflammatory response, which could chart the development of GM-related treatment interventions for both diseases. We conclude by exploring the therapeutic potential of GM in alleviating symptoms of AD and in reducing risk. Furthermore, we also propose future directions in AD research, namely fecal microbiota transplantation (FMT) and precision medicine.

Full Text

Full text is available at the source.

View full text (XML) ↗View full text ↗

Gut-brain axis through the lens of gut microbiota and their relationships with Alzheimer's disease pathology: Review and recommendations

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the gut-brain axis brief

Abstract

Full Text

Related papers

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the gut-brain axis brief