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Abstract
Alterations in gut microbiome composition and diversity are observed in both animal models and human patients with Alzheimer's disease.
- Gut microbiome dysbiosis is associated with increased intestinal permeability and impairment of the blood-brain barrier.
- Neuroinflammation linked to gut microbiome changes may contribute to the development of Alzheimer's disease hallmarks.
- Modulation of the gut microbiome could potentially alleviate symptoms of Alzheimer's disease or serve as a preventive measure.
- Type 2 Diabetes Mellitus frequently coexists with Alzheimer's disease, sharing common gut microbiome alterations and inflammatory responses.
- Exploration of therapies such as fecal microbiota transplantation and precision medicine may benefit Alzheimer's disease management.
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