Gut brain axis: an insight into microbiota role in Parkinson’s disease

Alterations in gut microbiota may indicate early signs of Parkinson's disease.

• Parkinson's disease is characterized by the presence of alpha-synuclein aggregates in the brain.
• Changes in gut microbiota are associated with alterations in short chain fatty acids, bile acids, and lipids.
• The gut-brain axis facilitates communication between the gut microbiota and the central nervous system.
• Dysbiosis, or imbalance in gut microbiota, could potentially be an early indicator of Parkinson's disease.
• Probiotics and fecal microbiota transplantation are proposed as alternative treatments to alleviate symptoms of Parkinson's disease.

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