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The role of gut dysbiosis in Parkinson’s disease: mechanistic insights and therapeutic options
How Imbalance in Gut Bacteria May Relate to Parkinson's Disease and Possible Treatments
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Abstract
Alterations in gut microbiota composition in Parkinson's disease may serve as early biomarkers of the disorder.
- Gastrointestinal symptoms in Parkinson's disease may precede motor symptoms.
- Unique changes in the gut microbiota are observed in patients with Parkinson's disease.
- The gut microbiota may influence neuroinflammation, barrier function, and neurotransmitter activity.
- There is a connection between the enteric nervous system and the central nervous system.
- The microbiota-gut-brain axis may be involved in the transmission of α-synuclein.
- Diet modification, probiotics, prebiotics, and fecal microbiota transplantation could be potential therapeutic approaches.
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