Ageing research reviews

Imbalance of Gut Bacteria and Their Chemicals in Parkinson's Disease

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Abstract

Alterations in gut microbial composition and metabolites may influence Parkinson's disease (PD).

  • Dysbiosis in gut microbiota can impact both the enteric and central nervous systems.
  • The microbiota-gut-brain axis may play a role in the development of CNS diseases.
  • Specific microbial products are associated with gut inflammation and neuroinflammation.
  • Future research should investigate particular gut microbes or metabolites linked to PD.
  • Microbiota-targeted interventions, including antibiotics and probiotics, may improve host health.

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