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Neuroprotective effects of fecal microbiota transplantation on MPTP-induced Parkinson’s disease mice: Gut microbiota, glial reaction and TLR4/TNF-α signaling pathway
Protective effects of gut bacteria transplant on Parkinson's symptoms in mice involving brain support cells and immune signaling
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Abstract
Gut microbiota from Parkinson's disease mice induced motor impairment and neurotransmitter decreases in normal mice.
- Alterations in gut microbiota composition were observed, with decreases in Firmicutes and Clostridiales and increases in Proteobacteria in fecal samples of PD mice.
- Higher levels of fecal short-chain fatty acids (SCFAs) were found in PD mice compared to normal mice.
- Fecal microbiota transplantation (FMT) alleviated physical impairment in PD mice and reduced gut microbial dysbiosis.
- FMT led to increased levels of dopamine (DA) and serotonin (5-HT) in the striatum of PD mice.
- Reduction in microglial and astrocytic activation in the substantia nigra was noted following FMT.
- FMT decreased the expression of components related to the TLR4/TNF-α signaling pathway in both gut and brain.
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