Exploring the gut-brain Axis: Potential therapeutic impact of Psychobiotics on mental health

Jun 24, 2024Progress in neuro-psychopharmacology & biological psychiatry

How gut-focused probiotics may help improve mental health

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Abstract

Psychobiotics may influence behaviors and central nervous system processes through the gut-brain axis.

Gut microbial metabolism is linked to neuropsychological disorders.
Psychobiotics have potential therapeutic effects on various conditions, including depression, anxiety, and neurodegenerative disorders.
The interaction mechanisms between psychobiotics and neuropsychological diseases remain to be fully understood.
Recent research highlights the need for further investigation into the gut-brain axis and the benefits of psychobiotics.

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One of the most challenging and controversial issues in microbiome research is related to gut microbial metabolism and neuropsychological disorders. Psychobiotics affect human behavior and central nervous system processes via the gut-brain axis, involving neuronal, immune, and metabolic pathways. They have therapeutic potential in the treatment of several neurodegenerative and neurodevelopmental disorders such as depression, anxiety, autism, attention deficit hyperactivity disorder, Alzheimer's disease, Parkinson's disease, schizophrenia, Huntington's disease, anorexia nervosa, and multiple sclerosis. However, the mechanisms underlying the interaction between psychobiotics and the abovementioned diseases need further exploration. This review focuses on the relationship between gut microbiota and its impact on neurological and neurodegenerative disorders, examining the potential of psychobiotics as a preventive and therapeutic approach, summarising recent research on the gut-brain axis and the potential beneficial effects of psychobiotics, highlighting the need for further research and investigation in this area.

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Exploring the gut-brain Axis: Potential therapeutic impact of Psychobiotics on mental health

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Recent issues from the gut-brain axis brief