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Gut‐brain axis serotonergic responses to acute stress exposure are microbiome‐dependent
Stress-related serotonin responses between the gut and brain depend on the gut microbiome
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Abstract
Microbiota influences the gastrointestinal serotonergic response to acute stress in a sex- and region-dependent manner.
- Male-specific increases in colonic serotonin after acute stress were absent in microbiota-deficient mice but normalized with colonization.
- Differential expression of serotonergic genes was observed in the colon and ileum of germ-free mice, varying by sex.
- The absence of the microbiome altered basal levels of serotonin and its main metabolite in the frontal cortex.
- Germ-free mice showed prevented stress-induced increases in serotonin turnover within the frontal cortex.
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