Gut-Brain Communication in Menopause: Insights into Neuroendocrine and Microbiome Interactions

Alterations in the gut microbiome are linked to menopausal transition.

• The gut microbiota communicates bidirectionally with the brain through neural, endocrine, and immune pathways.
• Menopause-associated estrogen decline disrupts gut-brain communication, affecting gastrointestinal function and microbial diversity.
• Changes in the gut microbiome may influence mood, cognition, and inflammation during menopause.
• The estrobolome, a community of gut bacteria, is capable of modulating circulating estrogen levels.
• Research suggests a complex interplay between intestinal microbiota and sex hormones that could contribute to menopausal symptoms and related health issues.
• Dietary strategies, lifestyle modifications, and targeted probiotics might help restore balance in the gut-brain axis during menopause.

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