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Not all gut cellular circadian oscillators are food entrainable
Some gut cells' daily rhythms are not controlled by food timing
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Abstract
Intestinal cell types exhibit unique circadian rhythms, with all major cell types showing self-sustained oscillators.
- Five major cell types in the intestine were examined for their circadian oscillators: enteric neurons, enteric glial cells, interstitial cells of Cajal, smooth muscle cells, and muscularis macrophages.
- All tested cell types displayed robust, self-sustained circadian bioluminescence rhythms, indicating they each contain cell-autonomous circadian oscillators.
- Circadian oscillators in enteric neurons, enteric glial cells, smooth muscle cells, and muscularis macrophages synchronized with feeding-fasting cycles.
- Interstitial cells of Cajal did not align their circadian rhythms with food intake, suggesting they have distinct entrainment properties.
- Feeding during inactive periods led to varied phase shifts in circadian rhythms among different intestinal cell types, potentially causing misalignment in gut circadian regulation.
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