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Maternal eating behavior is a major synchronizer of fetal and postnatal peripheral clocks in mice
Mother's eating patterns help set the body clocks of unborn and newborn mice
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Abstract
A robust diurnal rhythm of Rev-Luc was observed mainly in liver, intestine, kidney, and adipose tissues.
- Endogenous circadian clocks influence key biological processes in living organisms.
- The Rev-Luc mouse model allows for noninvasive, longitudinal tracking of peripheral clock oscillations.
- Rev-Luc expression in peripheral tissues is food-entrainable and remains unaffected by age or sex.
- The expression of Rev-Luc develops dynamically during fetal and postnatal growth.
- Maternal feeding regimens primarily influence the immature peripheral circadian system of offspring in utero.
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